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It depends on the organization's unique needs. The main advantages of a large cloud services provider such as Amazon are consistency and predictability. Large cloud disaster recovery providers offer rock-solid reliability (at least most of the time) and typically will give you a financially backed cloud service-level agreement (SLA).
Large cloud services providers can also offer access to an extensive documentation library. This means you can get the answers to all your technical questions before you sign up for the service, so you know exactly what the service is -- and is not -- capable of. In short, the SLA and documentation give you a predictable experience.
The disadvantage with a major cloud services provider is that you are unlikely to get service tailored to your needs. Conversely, smaller providers may be willing to work with you to put a system into place that fully meets your needs.
The disadvantage with a smaller cloud services provider is the issue of limited resources. Smaller providers are unlikely to have data centers all over the world or the ability to significantly ramp up capacity for many customers at a moment's notice (following a regional disaster).
In my opinion, you are probably better off going with one of the large providers so long as it meets your requirements.
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